Room-temperature ionic liquids
(RTIL) are molten salts with melting point below 100 °C. They have distinctive
properties and thus they were used for catalysis, separations, mass
spectrometry, and other.
They have been applied as ion
pairing reagent for electrospray ionization mass spectrometry (ESI-MS), solvent
for liquid-liquid extraction, stationary
phases for chromatography and as solvents in electrochemistry. The
materials have many properties that enhanced and improved the analysis using
mass spectrometry.
In general, the typical mass spectrometer is
consist of five parts; inlet for the sample, ion source, analyzer, detector and
vacuum. The main roles of ionic liquids in mass spectrometry are mainly focused
in the improvement of the analyte ionization, as solvent and as ion-pairing
reagent for ESI-MS.The present review is a tutorial article for researchers who
seek about the application of ionic liquids for mass spectrometry.
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