In this study, a
novel approach is proposed for determination of methylphenidate in biological
fluids. In this method molecularly imprinted solid-phase extraction (MISPE), as
the sample extraction technique, combined with high-performance liquid
chromatography (HPLC) is used.
The
water-compatible molecularly imprinted polymers (MIPs) were prepared using
methacrylic acid as functional monomer, ethylene glycol dimethacrylate as
cross-linker, Hexane as porogen and methylphenidate as template molecule.
Extraction of
methylphenidate from human serum was carried out using a novel imprinted
polymer as the solid-phase extraction (SPE). Various parameters affecting the
extraction efficiency of the polymer were evaluated.
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