Apoptosis is an
implicit cell suicide pathway which plays a pivotal role in both normal and
pathophysiological conditions. The intrinsic apoptotic pathway is tightly
regulated by BCL-2 family proteins.
In order to
trigger apoptosis in cancerous cells, several chemotherapeutic agents were
being used as anticancer agents, but still novel compounds are explored for
enhanced chemoprevention.
The computational
approaches towards screening of active compounds made easier to ascertain their
possible mechanism of action before experimental trials. Orientin, the
C-glycoside of luteolin (Luteolin-8-C-glucoside) is known to exert the
promising cytotoxic effect in human cancer cell lines.
No comments:
Post a Comment