Dan-Deng-Tong-Nao
capsules (DDTNCs), a traditional Chinese medicinal preparation consisting of
Radix Salvia miltiorrhiza, Radix Pueraria lobata, Erigeron breviscapus, Rhizoma
chuanxiong has been used for the treatment of apoplexy and the syndrome of
apoplexy involving both collaterals and meridians caused by obstruction of
collaterals by blood stasis in China.
In this paper, a
HPLC-DAD-MS/MS method was successfully developed for qualitative
and quantitative analysis of major components in DDTNCs for the first time.
Twenty-six
compounds were identified by comparison of their retention times and MS spectra
with those elucidated standards or recorded literatures, and six of them
(danshensu, 5-hydroxymethylfurfural, 3,4-dihydroxybenzaldehyde, epicatechin,
puerarin and salvianolic acid A) were simultaneously determined by HPLC-DAD
quantitatively.
