A novel
processing method for the manufacturing of slow-release particles is proposed.
The method is based on the wet milling of active compounds and the selected
biodegradable polymers combined with subsequent drying.
In the proposed
method the dissolution barrier is processed in one step compared to traditional
methods consisting of several steps. The experimental
dissolution curves of natural polymer (native potato starch and lignin)
coated salts were compared with unmilled and milled salts.
The dissolution
process model was developed in order to characterize and to design sustained
release particles. Models were verified with the existing dissolution data.
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