Aerosol Hygroscopic Growth as a New Factor for Trace and Ultra-Trace Determination of Phosphorous in Flame Containing Optical Trapping-Cavity Ring-Down Spectroscopy

A new method has been introduced based on aerosol hygroscopic growth as a new factor for trace and ultra-trace determination of phosphorous in flame containing optical trapping-cavity ring down aerosol extinction (emission) spectrometer (OT-CRD-AES).

In this study, a cavity ring down has been designed using hydrogen and air as fuel and oxidant during introduction of the aerosols containing phosphorous species using an ultrasonic generator (humidifier) from an acidic solution by a flow rate of N2 , followed by detection of the Mie scattering using a charged coupling device (CCD) system.

Parameters having strong influence during following scattering of the aerosols during their hygroscopic growth inside the humidified flame (H2 /air), include: influence and amount of Na+ as radiation buffer (as light source), flow rates of H2 , air and N2 , kind and concentrations of acid, evaluation of the aerosols inside flame, etc.

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Deep-UV Laser Ablation Technology Coupled with Plasma Quadrupole Mass Spectrometry for Rapid Determination of Nickel

Knowledge of nickel/vanadium (Ni/V) ratios in petroleum fuel is essential to source geochemical information and to limit catalytic poisoning and corrosive effects in chemical refining processes.

However, these ratios have been found to vary widely and are affected by various factors, including the sulphur content of the petroleum feedstock. They are normally obtained by digesting and treating the feedstock in suitable acid or organic media followed by numerical analysis.

Our research investigated a novel sample introduction technique for obtaining Ni/V ratios by ablating petrified asphaltene samples (following liquid nitrogen pre-treatment) with a 213 nm laser beam coupled to a hyphenated plasma mass spectroscopic system.

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Tobacco Smoke-Induced Alterations in Hepatic Lipid Profiles Demonstrated by Imaging Mass Spectrometry

To account for differences in susceptibility to alcoholic liver disease (ALD), tobacco smoking should be evaluated as a potential cofactor given the very high percentage of heavy drinkers also smoke, and the NNK tobacco-specific nitrosamine was shown to cause steatohepatitis and exacerbate molecular and biochemical effects of alcohol on the liver.

Since one of the key factors linked to ALD progression is dysregulated lipid metabolism, we examined effects of cigarette smoke (CS) exposures on hepatic lipid profiles using matrix-assisted laser desorption and ionization imaging mass spectrometry (MALDI-IMS).

Adult male A/J mice were exposed to air (8 weeks; A8), CS for 4 (CS4) or 8 (CS8) weeks; or CS8 with 2 weeks recovery (CS8+R). MALDI-IMS demonstrated broad CS-associated reductions in hepatic phospholipids that were partly ameliorated by short-term recovery.

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Tobacco Smoke-Induced Alterations in Hepatic Lipid Profiles Demonstrated by Imaging Mass Spectrometry

To account for differences in susceptibility to alcoholic liver disease (ALD), tobacco smoking should be evaluated as a potential cofactor given the very high percentage of heavy drinkers also smoke, and the NNK tobacco-specific nitrosamine was shown to cause steatohepatitis and exacerbate molecular and biochemical effects of alcohol on the liver.

Since one of the key factors linked to ALD progression is dysregulated lipid metabolism, we examined effects of cigarette smoke (CS) exposures on hepatic lipid profiles using matrix-assisted laser desorption and ionization imaging mass spectrometry (MALDI-IMS).

Adult male A/J mice were exposed to air (8 weeks; A8), CS for 4 (CS4) or 8 (CS8) weeks; or CS8 with 2 weeks recovery (CS8+R). MALDI-IMS demonstrated broad CS-associated reductions in hepatic phospholipids that were partly ameliorated by short-term recovery.

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One-Pot Synthesis of Substituted N-Phenyl Pyrazoles Using Ionic Liquid

Pyrazole containing natural products are very rare and such heterocycles are frequently encountered in agrochemicals, pharmaceuticals, materials science, and synthetic chemistry.

Compounds bearing the pyrazole nucleus, in particular, have exhibited a wide spectrum of therapeutic application and a plethora of drugs have progressed to the market, such as lonazolac, fipronil, Viagra, celecoxib, and many others.

Pyrazoles also constantly act as essential building blocks of ligands for transition metals, supermolecules, and liquid crystals.

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In Silico Molecular Docking Analysis Of Orientin, A Potent Glycoside of Luteolin against BCL-2 Family Proteins

Apoptosis is an implicit cell suicide pathway which plays a pivotal role in both normal and pathophysiological conditions. The intrinsic apoptotic pathway is tightly regulated by BCL-2 family proteins.

In order to trigger apoptosis in cancerous cells, several chemotherapeutic agents were being used as anticancer agents, but still novel compounds are explored for enhanced chemoprevention.

The computational approaches towards screening of active compounds made easier to ascertain their possible mechanism of action before experimental trials. Orientin, the C-glycoside of luteolin (Luteolin-8-C-glucoside) is known to exert the promising cytotoxic effect in human cancer cell lines.

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Forced Degradation Study of Monoclonal Antibody Using Two- Dimensional Liquid Chromatography

Monoclonal antibody (mAb) products are extraordinarily heterogeneous due to the presence of a variety of enzymatic and chemical modifications, such as deamidation, isomerization, oxidation, glycosylation, glycation, terminal cyclization, aggregation, and fragmentation.

Forced degradation study is a common practice to assess the potential modifications and degradation pathways of mAbs upon extreme conditions, including light exposure and extreme local pH.

The degraded samples are subject to characterization using a wide array of analyses, including ion exchange chromatography (IEC) for charge variants and size exclusion chromatography (SEC) for size variants.

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