Interpenetrating hydrogels with advanced
stiffness were prepared from the iron-alginate and cross-linked
poly(acrylamide). Multiple approaches were combined in order to prepare
hydrogels with mechanical properties required for various biomedical
applications.
Final properties of these materials were
studied in terms of their water content and elastic modulus. Special
attention was paid to describe the relationship between final properties
and the nature of alginate crosslinks (bivalent or trivalent ions).
Parameters such as concentration and nature of
the alginate, crosslinking density of poly(acrylamide) network, IPN formation
procedure were studied and adapted for obtaining the desired materials.
Compared to the simultaneous synthesis procedure, the two-step process was
found to be absolutely necessary for effective miscibility of two highly
crosslinked networks.
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